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Point-of-care testing for hypercoagulability in women with suspected pregnancy-related thromboembolism: results from the Caprini-Thrombin-Risk-Scoring (CTRS) study.
To determine how a modified Caprini risk scoring system would perform as a point-of-care (POC) test for hypercoagulability in pregnant women. A total of 1,046 pregnant women suspected of having a deep venous thrombosis (DVT) or pulmonary embolism (PE) underwent a combined clinical evaluation and POC testing for hypercoagulability. To calculate the risk for venous thromboembolism (VTE), the score was multiplied by 2 for first-trimester DVT/PE or 3 for second-trimester DVT/PE. In a subset of 532 patients with a VTE score >/=3, the prevalence of a hypercoagulable state as defined by a thrombin-antithrombin (TAT) or an antiphospholipid (APL) antibody was compared with that obtained with the standard laboratory tests. The measured TAT and APL antibody titers were higher in thrombotic women than in controls (P 15 nM or an APL antibody level >10 UI/mL, the sensitivity was 88% and 86%, respectively, and the specificity was 93% and 97%, respectively. The POC test for hypercoagulability in pregnant women is simple, rapid, and reliable. It can safely be used as a screening test for hypercoagulability in pregnant women with suspected VTE.Let z(s) = -2*s**3 – 20*s**2 – 50*s – 94. Determine z(-8).
158
Let g(j) = 5*j**2 + 38*j – 106. What is g(-10)?
14
Let d(u) = -u**2 – 9*u
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