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Retrieved January 26, 2011. “[7]” –> “This section shall be used for citation or referencing only.” “⦠The preliminary literary works and .
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Our knowledge of the uric acid (UA) pathophysiology has increased considerably in the last two decades. Hyperuricemia, an independent cardiovascular risk factor, causes gout, a condition that is getting more and more recognized in the light of new epidemiological data and the successful therapy of patients with low serum urate. At present, the interest of the clinician is mainly focused on the effects of UA on the severity and clinical course of myocardial infarction, diabetes, hypertension, atherosclerosis, and arteriosclerosis. A possible role of UA in the genesis of hypertension and atherosclerosis is suggested by the pathogenic mechanisms that have been suggested as a consequence of the stimulatory effect of UA on platelet aggregation, blood viscosity, and the synthesis of proinflammatory factors. Experimental studies have shed new light on the role of UA as a causal factor in vascular injury. The potential benefit from urate-lowering therapy was demonstrated in two randomized clinical trials. In hypertensive patients, a low-dose allopurinol regimen reduces albuminuria and proteinuria, blood pressure, and the incidence of new albuminuria and death. In patients with established atherosclerosis, a uricosuric agent reduces the extent and progression of atherosclerotic lesions. Although recently a genetic association between serum UA and myocardial infarction and ischemic stroke was described, this does not exclude the possibility that the current therapeutic approaches may be useful in the primary and secondary
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Creative Writing On The BBC. From the very inception of the BBC, it has reflected our culture and has acted as a mirror to the nation. I hope you also remember the great aspects of the organization’s history.
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Creative Writing On The BBC. From the very inception of the BBC, it has reflected our culture and has acted as a mirror to the nation. I hope you also remember the great aspects of the organization’s history.
Creative Writing On The BBC. From the very inception of the BBC, it has reflected our culture and has
