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Recently, we identified two subpopulations of Tregs, one of which produces IL-10. We further investigated whether IL-10-producing tumor-infiltrating lymphocytes (TIL-10) have suppressive function and examined whether their suppressive function was associated with clinical outcome. In this study, we collected tumor samples from 134 patients with primary gastric cancer and analyzed their immunological characteristics. We found a good correlation between TIL-10 frequency and tumor progression. TIL-10 showed suppressive function on the expression of several inflammatory cytokines and tumor antigen-specific T-cell proliferation. TIL-10+ cells could induce apoptosis in effector T cells. We also showed that IL-10 produced by TIL-10 suppressed the suppressive function of CD4+CD25+ Tregs. Our results indicate that TIL-10 could play a role as an anti-tumor activity in the local microenvironment by inhibiting the suppressive function of Tregs.Q:
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The Hong Kong Monetary Authority (HKMA) has published a draft of the annual report on the Hong Kong’s Permanent Fund for the year ending December 31, 2019.
The report shows that the Hong Kong Permanent Fund’s investment in blockchain technology was HK$6.22 billion in the past year. In addition, the fund invested an additional HK$12.81 billion in open-ended funds for investment in newly listed or not-yet listed securities.
The Hong Kong Monetary Authority issued a draft of the annual report on the Hong Kong’s Permanent Fund for the year ending December 31, 2019. The report reveals that the Hong Kong Permanent Fund invested over HK$12.81 billion in open-ended funds for investment in newly listed or not-yet listed securities.
The Hong Kong Financial Secretary revealed that HKMA is taking steps to support Hong Kong’s fintech industry and blockchain development. They foresee the city as a global center for asset management, asset tokenization, and digital assets.
Speaking to the Financial Secretary, Cheung Ka-po (張嘉婆), Chief of the Hong Kong Permanent Fund, said that the two most important projects they are working on are the Hong Kong Digital Trust (HKDT) and the HK Digital Trust Alliance (HKDTA).
Cheung said that HKDT will become the trust of the Hong Kong Blockchain ecosystem and HKDT will also integrate with the smart city strategy. HKDTA will help the city to be a digital frontier, and HKDTA will include 80+ fintech companies, blockchain ecosystems and startups in Hong Kong.
HKMA’s Assets Committee Managing Director commented on the report by saying: “In the financial year under review, the Hong Kong Permanent Fund made positive use of the special privileges granted to it.”
Co-Chairman of the Hong Kong Monetary Authority, Brooks Ashman, says that “We are pleased to see
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