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The effect of 5-HT1A receptor agonists on the behaviour and spine density in the prefrontal cortex of chronically treated 6-hydroxydopamine rats.
The purpose of the present study was to examine whether repeated administration of the selective 5-HT1A receptor agonists (+)-WAY-100135 (WAY) or (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT) modified the 6-hydroxydopamine (6-OHDA)-induced depletion of dopaminergic afferents in the prefrontal cortex (PFC) of rats. The release of noradrenaline (NA), serotonin (5-HT) and dopamine (DA) was also studied in the PFC of 6-OHDA-lesioned rats following repeated treatment with (+)-WAY and (+/-)-8-OH-DPAT. The present results demonstrate that the lesion of the nigrostriatal pathway induced a depletion of the DA-containing axons in the PFC which could be attenuated by the repeated administration of (+)-WAY. However, 8-OH-DPAT induced a similar attenuation of the lesion-induced DA depletion without affecting the concentrations of 5-HT and NA in the PFC of 6-OHDA rats. A close relationship has previously been reported between the DA and 5-HT system in the PFC and it is possible that this relationship was also evident in this study. The present results indicate that the role of the 5-HT1A receptor in modifying the 6-OHDA-induced depletion of DA in the PFC was modulated by the selective release of DA.Community policing and the Council on Accreditation
What’s the Council on Accreditation?
The Council on Accreditation is a resource of education, review, and certification that has been adopted as the method of education and training by the Canadian Association of Chiefs of Police and the Canadian Association of Police Supervisors and Administrators (CAPSA).
What is community policing?
Community policing is a philosophy of law enforcement that emphasizes partnerships with the community as the source of crime prevention and public trust. It is a way of thinking about law enforcement that tries to understand why certain crimes occur and what can be done to deter them.
Association of Chief Policing Executives (ACPE) supports police services being community based, involving both the police and members of
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