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That includes keeping and maintaining the vehicle on the road; finding the best deal on the next vehicle; and even avoiding the recurring ‘typical’ repairs..Modification of the binding of [3H]SCH 23390 to dopamine D2 receptors after long-term in vitro treatment with cocaine.
We previously showed that in vitro treatment of rat striatal membranes with cocaine induced a modification of the binding properties of [3H]SCH 23390 to dopamine D2 receptors. The purpose of the present study was to examine the effect of this long-term treatment on the binding of [3H]SCH 23390 to striatal membranes of both in vitro and in vivo (cocaine-susceptible and -insensitive) rats. The in vitro treatment with 1 mM cocaine for 18 hr induced a decrease in the maximal density of [3H]SCH 23390 binding sites, together with a decrease in affinity (increased Kd values), in the membranes of the in vitro cocaine-susceptible but not the in vitro cocaine-insensitive rats. In vivo treatment with cocaine (20 mg/kg, i.p.) for 8 days induced the same changes in the binding of [3H]SCH 23390 to striatal membranes of in vitro cocaine-susceptible rats. Interestingly, in vivo treatment of cocaine-insensitive rats with cocaine (20 mg/kg, i.p.) for 8 days did not change either the affinity (Kd) or maximal density of [3H]SCH 23390 binding sites. The in vitro treatment of rat striatal membranes with cocaine has not only a long-term effect on the binding of [3H]SCH 23390 to striatal dopamine D2 receptors but also, in vivo, a modification of the binding of [3H]SCH 23390 to striatal dopamine D2 receptors. This long-term effect of cocaine on the binding of [3H]SCH 23390 to dopamine D2 receptors could be involved in the enhancement of the behavioural effects of cocaine.using System;
using System.Collections.Generic;
using System.Data;
using System.Data.SqlClient;
using System.Linq;
using System.Text;
using System.Threading.Tasks;
namespace TestWcfService.DataClasses
{
public class AResult
{
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