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FC MpTool FC8308 FC8508 FC8406 V03.rar downloade bearbeitunIn vitro effect of propafenone on drug-induced arrhythmias in the guinea-pig heart.
Propafenone, a new antiarrhythmic drug and also the R-(+)-isomer of propafenone N-oxide, was studied for its antiarrhythmic properties in an in vitro model for ischaemia-induced arrhythmias in guinea-pig heart. A dose-dependent reduction in frequency and amplitude of the fibrillation-like ventricular ectopic impulse induced by ischaemia was shown. Propafenone reduced the ventricular ectopic impulse in a concentration range of 10(-5) M to 10(-3) M. In the ischaemic guinea-pig heart, propafenone had significant antiarrhythmic properties even at 10(-5) M concentration (Emax: 66%). The EKG pattern of the fibrillation-like ectopic impulse was also unaffected by propafenone. The antiarrhythmic activity of propafenone (10(-5) M) was antagonized by prior exposure of the heart to the concentrations of epinephrine that induced the arrhythmia. However, propafenone (10(-4) M) had no effect on adenosine-induced arrhythmias. It is suggested that the antiarrhythmic effect of propafenone in the guinea-pig heart is mainly due to the antagonism of the positive inotropic effect of adrenergic stimulation.N-κ-B nuclear transcription factors
N-κ-B nuclear transcription factors are proteins that are involved in the transcription of a number of cellular genes by binding to specific DNA sequence elements. They play an important role in the response to a variety of stresses. N-κ-B transcription factors share a domain of approximately 100 amino acids that binds to a specific DNA sequence known as the κB site.
The subfamilies of N-κ-B transcription factors
There are two major groups of N-κ-B transcription factors that are involved in defense
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