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The majority of gastrointestinal tumors are usually diagnosed by pathological evaluation and histological assessment of samples obtained by endoscopy, surgery or biopsy. However, this approach is not always adequate as it has a high rate of false-positive results. For instance, benign endocrine tumors or tumors of unknown origin may appear as malignant neoplasm at biopsy, while some metastatic neoplasms show only a typical morphology. Additional diagnostic procedures might be needed, but they are also a source of unnecessary discomfort and morbidity to the patient. Therefore, in the last decade, a number of novel biomarkers have been identified and assessed in an attempt to discover new tools for discriminating neoplasms from healthy tissues. Extensive studies have shown that microRNAs (miRNAs), a class of non-coding RNAs of ~22 nucleotides, can be used to identify cancer as well as cancer-specific miRNAs. Recently, several reports have described the role of miRNAs as diagnostic and prognostic markers in different solid cancers. The aim of this review is to describe the alterations in miRNAs expression patterns in gastric, esophageal, colon, pancreatic and rectal cancer, and to explore the diagnostic potential of miRNAs for digestive tumors. The identification of the miRNA signature in tumor-derived cell lines and clinical samples has been restricted to a few studies so far, but the results suggest that miRNAs may be useful as diagnostic biomarkers of digestive tumors.Is curiosity a necessity for learning? A pilot study on the learning curve of laparoscopic ventral hernia repair.
The learning curve of laparoscopic ventral hernia repair (LHVHR) has been extensively studied and described in the last decade. There is no consensus on the number of procedures that the surgeon must perform to reach a minimal level of competence. In this study, we attempt to answer the question: is the level of curiosity required to succeed in learning LHVHR? The data of all LHVHRs performed by the same surgical team from July 2014 to April 2015 in an academic surgical center were reviewed. Data on patients’ characteristics, operative data, complications, and conversion rate were collected. One hundred nine cases
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