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Long noncoding RNAs (lncRNAs) have been recently shown to be involved in numerous biological processes through their localization in the nucleus, yet, the role of nuclear localization signals (NLSs) on lncRNAs is still unknown. Since the minimum length requirement of a functional NLS can range between 30 and 50 amino acids, they are readily located in the C-termini of proteins. Herein, we aimed to identify the functional NLSs in lncRNAs, and investigate whether these identified lncRNA NLSs (hnRNAL NCIS) are conserved among the members of human and mouse genomes. We used bioinformatics approaches to reveal the presence of hnRNAL NCIS among conserved lncRNAs using for the analysis two different databases: GeneCards® and Gencode. We classified lncRNAs based on the identification of hnRNAL NCIS. We found that different human and mouse lncRNAs have a core region which contains the
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