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Download Full Version Cracked Softwares Here. Crack Serial Keygen Free 100%.Protein phosphorylation and dephosphorylation is a rapid regulatory process required for the action of hormones and other signaling molecules. Protein kinases add a phosphate group to a protein. Protein phosphatases remove phosphate groups from proteins. Phosphatases are classified into two families based on substrate specificity, one being serine/threonine phosphatases and the other being tyrosine phosphatases.
Prostaglandin E2 (PGE2) has been implicated in a number of physiological actions including pain, inflammation and fever. PGE2 mediates these effects via four receptor subtypes termed E prostanoid (EP) receptors, designated EP1, EP2, EP3, and EP4. The EP4 receptor has been shown to mediate the effects of PGE2 on fever, pain, and inflammation (Vane, et al., Br. J. Pharmacol. 1999, 127, 597-606). However, the role of the EP4 receptor in inflammation is unclear because it has been reported to both reduce (Tsutsumi et al., J. Biol. Chem. 1997, 272, 31911-31916) and increase (Yoshioka et al., Biochem. Biophys. Res. Commun. 1997, 232, 72-76; Wang et al., Br. J. Pharmacol. 1999, 128, 1858-1864) the production of TNF-alpha.
In view of the role of EP4 in fever, pain, and inflammation, the compounds of the present invention are believed to be useful in the treatment of pain, fever, and inflammation.The role of inflammation in the pathogenesis and clinical course

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