Selection Professional 2.0 Hettich.epub

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Selection Professional 2.0 Hettich.epub

Data filtering was implemented by using the Venn Diagrams tool of the R script. This tool is included in the package for identification and selection of genes that are either differentially expressed, or show a consistent and statistically significant increase or decrease under specific conditions. [10] [20] [21]

Major goals of prosthetic valve design are to optimize the hemodynamic function of the implanted valve and to minimize prosthesis-related complications. This might be achieved by the physiological implantation technique, by minimizing the potential for thrombosis or embolism, by a nonrestrictive design, by a biocompatible and durable material, and by the optimal selection of valve size and valve type. The prosthetic valve hemodynamics is determined by the implanted valve geometry and physical properties, mitral valve anatomy and function, and the characteristics of the surrounding environment (heart). In addition, the patient-related risk factors, such as age, race, comorbidities, and frailty, as well as the quality of postoperative care, are important determinants of outcome and may be optimized through optimal patient selection. Valve selection depends on the anatomic and pathophysiologic severity of the native valve disease, its impact on left ventricular function, and the risk of thromboembolic and anticoagulant-related events. This article provides an overview of the contemporary literature regarding the hemodynamics of the different currently available prosthetic valves, as well as strategies to minimize the impact of valve mismatch in patients undergoing valve replacement. Moreover, other aspects of prosthetic valve selection are discussed including nonrestrictive design, valve durability, prevention of thrombosis, and management of anticoagulation.

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