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Malnutrition adversely affects the outcome after renal transplantation. It is challenging to detect malnutrition in renal transplant recipients (RTRs). Hypophosphatemia has been suggested as a diagnostic biomarker for malnutrition in RTRs. However, the pooled sensitivity and specificity of hypophosphatemia in RTRs have not been well documented in the literature. A systemic review of the literature to evaluate the role of hypophosphatemia in diagnosing malnutrition in RTRs was undertaken. A systematic review of the literature was conducted in Medline, Embase, Web of Science, Cochrane Library, and other search engines, and references of the full-text articles were reviewed. Studies that examined the prevalence of hypophosphatemia in RTRs who were malnourished compared with those who were not malnourished were considered. Sensitivity and specificity of hypophosphatemia in identifying malnutrition in RTRs were calculated. Twenty-seven studies, including 21 cohort studies and six case-control studies, fulfilled the inclusion criteria. In the studies evaluating malnutrition (malnourished vs not malnourished), the pooled sensitivity of hypophosphatemia in identifying malnourished RTRs was 88.2% (95% confidence interval [CI]: 84.4%-90.5%) and the pooled specificity of hypophosphatemia was 94.4% (95% CI: 88.8%-97.5%). The current results indicate that hypophosphatemia could be a useful biomarker for identifying malnutrition in RTRs.HIV-2 (ZR53/98) infection in a new human breast epithelial cell line.
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